Evorel® Conti

The name of your medicine is Evorel Conti 50mg Estradiol and 170mg Norethisterone Acetate per 24 hours Transdermal patch.  Evorel Conti is a Hormone Replacement Therapy (HRT). It contains two types of female hormones, an oestrogen and a progestogen. Evorel Conti is used in postmenopausal women with at least 18 months since their last natural period.

Evorel Conti comes in a pack that helps you to remember when to change your patches. Each pack contains eight patches. The hormones are spread evenly in each patch. They pass slowly into your body through the skin

During the menopause, the amount of the oestrogen produced by a woman’s body drops. This can cause symptoms such as hot face, neck, and chest (“hot flushes”). Evorel Conti alleviates these symptoms after menopause. You will only be prescribed Evorel Conti if your symptoms seriously hinder your daily life.

It is suitable for women who have been post-menopausal for 6 months. This is usually taken to be 18 months after the last period (menstrual bleed), but your doctor will advise you.

Evorel Conti is known as ‘continuous combined’ HRT. This is because both hormones in the patch are released all the time.

Evorel Conti patches replace the oestrogen that is normally released by the ovaries. However, in women who still have a womb, taking an oestrogen hormone regularly may cause the lining of your womb to build up and get thicker
• This means it is necessary to add a progestogen hormone to the oestrogen
• This helps shed the lining of the womb and stop any problems happening.

This is why Evorel Conti patches also contain a progestogen

Most women do not have a regular monthly period with Evorel Conti. However, bleeding or spotting does often occur in the first few months until treatment settles down.

Evorel Conti is not a contraceptive. If it is less than 12 months since your last menstrual period or you are under 50 years old, you may still need to use additional contraception to prevent pregnancy. Speak to your doctor for advice.

Always use Evorel Conti exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure. Your doctor will aim to reduce your symptoms with the lowest possible dose for the shortest amount of time.

Put an Evorel Conti patch on at the end of a treatment cycle or two weeks after you finish using another HRT product if:

  • You are changing from an HRT medicine that gives you a withdrawal bleed

If you are using another type of HRT:

  • The day you start will depend on the type of HRT you have been using

Talk to your doctor if you are not sure which type of HRT you are using.

You may put an Evorel Conti patch on at any time if:

  • You have not been using another type of HRT

Using the patches

The patches need to be changed twice a week. Start a new pack of Evorel Conti as soon as you finish one. Do not leave a break between packs.

Changing your patches

  • You must change the patches twice a week to give your body a steady supply of hormones.
    There is enough hormone in each patch to last for several days
  • Change your patch on the same two days every week. This will mean that one patch is on for three days and the next patch for four days
  • For example, if you apply your first patch on a Monday, change it on Thursday and again on the following Monday

Stick the patch onto a hairless area of skin below the waist. Most women prefer to wear the patch on the thigh or bottom.

  • Do not apply on or near the breasts
  • Do not put it on top of cuts, spots or anywhere the skin is irritated
  • Do not use cream, moisturiser or talc before applying the patch
  • Do not apply the patch on the same area of skin twice in a row
  • It can be worn under loose areas of clothing. Do not wear a patch under elasticated areas or a tight waistband
  • Apply the patch to clean, dry, cool skin as soon as you open the protective pouch

Apply a new patch but keep to your original ‘patch change’ days. If you have just had a bath or a shower, wait until your skin cools before applying the new patch. Talk to your doctor if you need more patches.

Change it as soon as you remember and then keep to your original ‘patch change’ days. You may get some bleeding and spotting like a period during this time.

Frequently asked questions about Evorel®

It is unlikely that you will have too much of the hormones in Evorel Conti. The most common symptoms of having too much oestrogen or progestogen in your body are:

  • Tender breasts
  • Feeling sick (nausea) or being sick
  • Unexpected vaginal bleeding
  • Stomach pain or bloating
  • Feeling depressed
  • Tiredness
  • Acne
  • Growth of body or facial hair

Removing the patch can reverse the effects of too much oestrogen and/or progestogen. Talk to your doctor or pharmacist before using any more patches.

The levels of hormone from the patches are too low to act as a contraceptive. Talk to your doctor for advice on contraception.

  • You can have a bath or shower as normal. Do not scrub too hard as this can loosen the edges of the patch
  • You can go swimming. The patch will not be affected
  • You can exercise and play sports. However, do not wear the patch under tight clothing or waist bands
  • You can sunbathe. However, keep the patch covered, out of direct sunlight

Like all medicines, this medicine can cause side effects, although not everybody gets them.

The following diseases are reported more often in women using HRT compared to women not using HRT:

  • breast cancer
  • abnormal growth or cancer of the lining of the womb (endometrial hyperplasia or cancer)
  • ovarian cancer
  • blood clots in the veins of the legs or lungs (venous thromboembolism)
  • heart disease
  • stroke
  • probable memory loss if HRT is started over the age of 65

Excessive thickening of the lining of the womb (endometrial hyperplasia) and cancer of the lining of the womb (endometrial cancer)

HRT is not recommended for women who have ever had cancer of the lining of the womb.

Using oestrogen-only HRT will increase the risk of excessive thickening of the lining of the womb (endometrial hyperplasia) and cancer of the womb lining (endometrial cancer). The progestogen in Evorel Conti protects you from this extra risk.

How likely is endometrial cancer?

In women who still have a womb and who are not taking HRT, on average, 5 in 1,000 will be diagnosed with endometrial cancer between the ages of 50 and 65.

For women aged 50 to 65 who still have a womb and who take oestrogen-only HRT, between 10 and 60 women in 1,000 will be diagnosed with endometrial cancer (i.e. between 5 and 55 extra cases), depending on the dose and for how long it is taken.

The addition of a progestogen to oestrogen-only HRT substantially reduces the risk of endometrial cancer.

  • Women who have breast cancer or have had breast cancer in the past should not have HRT.

Evidence shows that taking combined oestrogen-progestogen or oestrogen-only hormone replacement therapy (HRT) increases the risk of breast cancer. The extra risk depends on how long you use HRT. The additional risk becomes clear within 3 years of use. After stopping HRT the extra risk will decrease with time, but the risk may persist for 10 years or more if you have used HRT for more than 5 years.

Women aged 50 to 54 who are not taking HRT, on average 13 to 17 in 1000 will be diagnosed with breast cancer over a 5-year period.

  • For women aged 50 who start taking oestrogen-only HRT for 5 years, there will be 16-17 cases in 1000 users (i.e. an extra 0 to 3 cases).
  • For women aged 50 who start taking oestrogen-progestogen HRT for 5 years, there will be 21 cases in 1000 users (i.e. an extra 4-8 cases).
  • Women aged 50 to 59 who are not taking HRT, on average, 27 in 1000 will be diagnosed with breast cancer over a 10-year period.
  • For women aged 50 who start taking oestrogen-only HRT for 10 years, there will be 34 cases in 1000 users (i.e. an extra 7 cases)
  • For women aged 50 who start taking oestrogen-progestogen HRT for 10 years, there will be 48 cases in 1000 users (i.e. an extra 21 cases).

If you notice any changes in your breast, such as:

· Dimpling of the skin

· Changes in the nipple

· Any lumps you can see or feel

Make an appointment to see your doctor as soon as possible.

Additionally, you are advised to join mammography screening programs when offered to you. For mammogram screening, it is important that you inform the nurse/healthcare professional who is actually taking the x-ray that you use HRT, as this medication may increase the density of your breasts which may affect the outcome of the mammogram. Where the density of the breast is increased, mammography may not detect all lumps.

Ovarian cancer

Ovarian cancer is rare, much rarer than breast cancer. The use of oestrogen-only or combined oestrogen-progestogen HRT has been associated with a slightly increased risk of ovarian cancer.

The risk of ovarian cancer varies with age. For example, in women aged 50 to 54 who are not taking HRT, about 2 women in 2000 will be diagnosed with ovarian cancer over a 5-year period. For women who have been taking HRT for 5 years, there will be about 3 cases per 2000 users (i.e., about 1 extra case).

Information placed on this digital platform is not intended as a substitute for consultation with your healthcare professional. Please consult your doctor or nurse for further information.

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