Evorel® 50

The name of your medicine is Evorel 50 micrograms per 24 hours Transdermal Patch.

  • Evorel belongs to a group of medicines called hormone replacement therapy (HRT).
  • Evorel contains an oestrogen (oestradiol) which is a female hormone.

Evorel is used for the symptoms of the menopause. These symptoms may be caused by a lack of naturally occurring oestrogens and progestogens. Evorel is also used to prevent osteoporosis (fragile bones) in women who have had the menopause and are most likely to have bone problems. It is suitable for women who have not had a period (menstrual bleed) for at least 18 months? It is only used if other medicines for osteoporosis have been tried first and they have not worked.

Evorel patches replace the oestrogen that is normally released by the ovaries.

However, in women who still have a womb, taking an oestrogen hormone regularly may cause the lining of your womb to build up and get thicker.

  • This means it is necessary to add a progestogen hormone to the oestrogen
  • This helps shed the lining of the womb and stop any problems happening

Evorel is not a contraceptive. If it is less than 12 months since your last menstrual period or you are under 50 years old, you may still need to use additional contraception to prevent pregnancy. Speak to your doctor for advice.

Always use Evorel exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure. Your doctor will aim to reduce your symptoms with the lowest possible dose for the shortest amount of time.

Evorel comes in a ‘memory pack’. This can be used to help you remember when to change your patches. Each pack contains eight patches.
The hormone is spread evenly in each patch. It passes slowly into your body through the skin

When to start using Evorel
Put an Evorel patch on at the end of a treatment cycle if:

  • You are changing from an HRT medicine that gives you a withdrawal bleed

You may put an Evorel patch on at any time if:

  • You have not used HRT before your menopause
  • You are changing from HRT that does not give you a withdrawal bleed

Talk to your doctor if you are not sure which type of HRT you are using.

Using the patches
The patches need to be changed twice a week. Start a new pack of Evorel as soon as you finish one. Do not leave a break between packs.

Changing your patches

  • You must change the patches twice a week to give your body a steady supply of hormones. There is enough hormone in each patch to last for several days
  • Change your patch on the same two days every week. This will mean that one patch is on for three days and the next patch for four days
  • For example, if you apply your first patch on a Monday, change it on Thursday and again on the following Monday.

Where to apply the patch
Stick the patch onto a hairless area of skin below the waist. Most women prefer to wear the patch on the thigh or bottom.

  • Do not apply on or near the breasts
  • Do not put it on top of cuts, spots or anywhere the skin is irritated
  • Do not use cream, moisturiser, or talc before applying the patch
  • Do not apply the patch on the same area of skin twice in a row
  • It can be worn under loose areas of clothing. Do not wear a patch under elasticated areas or a tight waistband
  • Apply the patch to clean, dry, cool skin as soon as you open the protective pouch

Apply a new patch but keep to your original ‘patch change’ days. If you have just had a bath or shower, wait until your skin cools before applying a new patch.

Talk to your doctor if you need more patches.

Change it as soon as you remember and then keep to your original ‘patch change’ days. You may get some bleeding and spotting like a period during this time.

Frequently asked questions about Evorel®

The levels of hormone from the patches are too low to act as a contraceptive.
Talk to your doctor for advice on contraception.

Breakthrough bleeding or spotting is usually nothing to worry about, especially during the first few months of using HRT.
But if the bleeding or spotting:

  • Carries on for more than the first few months
  • Starts after you have been on HRT for a while
  • Carries on even after you have stopped using HRT,

make an appointment to see your doctor as soon as possible. It could be a sign that your endometrium has become thicker.

It is unlikely that you will have too much of the hormones in Evorel. The most common symptoms of having too much oestrogen in your body are:

  • Tender or painful breasts
  • Feeling sick (nausea) or being sick
  • Unexpected vaginal bleeding
  • Stomach pain or bloating

Removing the patch can reverse the effects of too much oestrogen. Talk to your doctor or pharmacist before using any more patches. Your doctor may decide to change the size of patch.

Like all medicines, Evorel can cause side effects, although not everybody gets them. Some side effects may be due to any progestogen that is being taken at the same time.

The following diseases are reported more often in women using HRT compared to women not using HRT:

  • breast cancer
  • abnormal growth or cancer of the lining of the womb (endometrial hyperplasia or cancer)
  • ovarian cancer
  • blood clots in the veins of the legs or lungs (venous thromboembolism)
  • heart disease
  • stroke
  • probable memory loss if HRT is started over the age of 65

For further information, please consult the Patient Information Leaflet.

HRT is not recommended for women who have ever had cancer of the lining of the womb.

Using oestrogen-only HRT for a long time can increase the risk of cancer of the lining of the womb (the endometrium). Having a progestogen as well as the oestrogen helps to lower the extra risk.

If you still have your womb, your doctor will usually prescribe a progestogen as well as oestrogen. These may be prescribed separately, or as a combined HRT product.

If you have had your womb removed (a hysterectomy), your doctor will discuss with you whether you can safely have oestrogen without a progestogen.

If you have had your womb removed because of endometriosis, any endometrium left in your body may be at risk of cancer. This means your doctor may prescribe HRT that includes a progestogen as well as an oestrogen.
Your product, Evorel, is an oestrogen-only HRT.

How likely is endometrial cancer?
Looking at women aged 50 to 65 years, who still have a womb, on average,
over the next 15 years:

• In women not taking HRT – 5 in 1000 will get endometrial cancer
• In women taking oestrogen-only HRT, the number will be 2 to 12 times higher (an extra 5 to 55 cases), depending on the dose and how long you take it for.

The addition of a progestogen to oestrogen-only HRT substantially reduces the risk of endometrial cancer.

Women who have breast cancer, or have had breast cancer in the past should not have HRT.

Having HRT slightly increases the risk of breast cancer. The risk is also slightly increased if you have a later menopause.

  • Postmenopausal women taking oestrogen-only HRT for 5 years – the risk is about the same as for a woman of the same age who is still having periods over that time, and not taking HRT
  • Women taking oestrogen plus progestogen HRT – the risk is higher than for oestrogen-only HRT. However, oestrogen plus progestogen HRT isbeneficial for the endometrium (see ‘Endometrial cancer’)

For all kinds of HRT, the extra risk of breast cancer goes up the longer you take it. However, it returns to normal within about 5 years after stopping HRT. For women who have had their womb removed and who are using oestrogen-only HRT for 5 years, little or no increase in breast cancer risk is shown.

Your risk of breast cancer is also higher if:

  • You have a close relative (mother, sister, or grandmother) who has had breast cancer
  • You are very overweight

Looking at women aged 50 to 79, on average, over the next 5 years:

  • In women not taking HRT – between 9 and 17 in 1000 will get breast cancer
  • In women taking oestrogen-progestogen HRT at age 50 to 79, and take it for 5 years, between 13 and 23 in 1000 will get breast cancer (an extra 4-6 cases)

If you notice any changes in your breast, such as:

  • Dimpling of the skin
  • Changes in the nipple
  • Any lumps you can see or feel

Make an appointment to see your doctor as soon as possible.

Ovarian cancer
Ovarian cancer (cancer of the ovaries) is rare, much rarer than breast cancer. The use of oestrogen-only or combined oestrogen-progestogen HRT has been associated with a slightly increased risk of ovarian cancer.

The risk of ovarian cancer varies with age. For example, in women aged 50 to 54 who are not taking HRT, about 2 women in 2000 will be diagnosed with ovarian cancer over a 5-year period. For women who have been taking HRT for 5 years, there will be about 3 cases per 2000 users (i.e., about 1 extra case).

Information placed on this digital platform is not intended as a substitute for consultation with your healthcare professional. Please consult your doctor or nurse for further information.

The information on this website is intended for patients who have been prescribed Evorel or Evorel Conti that reside in the Republic of Ireland only.

Provide Feedback
close slider

Create your own user feedback survey